Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species

نویسندگان

چکیده

Understanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, is becoming increasingly important virology. Species barrier jumping has been extensively studied animal viruses, and the critical role a suitable intermediate host viruses-generated human pandemics highly topical. However, studies on involving plant viruses have focused shifting intra-species, leaving aside putative “bridge hosts” facilitating interspecies crossing. Here, we take advantage several VPg mutants, derived from chimeric construct potyvirus Plum pox virus (PPV), analyzing its differential behaviour three herbaceous species. Our results showed two mutations Nicotiana clevelandii-adapted virus, emerged during adaptation to bridge-host Arabidopsis thaliana, drastically prompted partial Chenopodium foetidum. Although both changes are expected facilitate productive interactions with eIF(iso)4E, polymorphims detected PPV eIF(iso)4E studied, extrapolated recent VPg:eIF4E structural model, suggested ways can be operating. Remarkably, found driving host-range expansion non-related species, not only associated cost trade-off constraints original host, but also improve fitness it.

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ژورنال

عنوان ژورنال: Microorganisms

سال: 2021

ISSN: ['2076-2607']

DOI: https://doi.org/10.3390/microorganisms9040805